Culture Supernatant-Containing Products for Home Care
Incorporating Regenerative Medicine into Daily Care

At AVAN TOKYO, we provide serums and creams containing stem cell culture supernatant for home care at your residence. In Ginza, you can incorporate regenerative medicine into daily skincare.
External products can enhance effectiveness when used in combination with clinic treatments. They are also effective as maintenance to sustain the effects of clinic treatments. By incorporating them into daily skincare routines, they continuously support the skin’s regenerative capacity.
What Are Culture Supernatant-Containing Products?

Culture supernatant-containing products are skincare products such as serums and creams formulated with supernatant obtained during the process of culturing adipose-derived stem cells. This supernatant contains abundant growth factors, cytokines, exosomes, and other bioactive substances, and supports the skin’s regenerative capacity when applied to the skin.
While ordinary cosmetics aim to moisturize the skin surface or temporarily condition the skin, culture supernatant-containing products aim to act upon skin cells and enhance the skin’s regenerative capacity itself. A distinguishing feature is that the same components used in clinic injection and delivery treatments can be used daily at home.
Products containing culture supernatant differ from ordinary cosmetics in that they contain active ingredients such as growth factors and exosomes. These components are expected to promote skin turnover, support collagen production, and enhance the skin barrier function.
Expected Effects

The following effects are expected from culture supernatant-containing products:
Enhancement of Skin Firmness and Elasticity
Through the action of growth factors, collagen and elastin production is promoted and enhancement of skin firmness and elasticity is expected. Effects are expected for those concerned about sagging.
Reduction of Fine Lines
Through improved skin moisture retention capacity and refined texture, fine lines becoming less noticeable is expected. Effects are expected for fine lines around the eyes and mouth.
Skin Tone Enhancement and Dullness Improvement
Through promoted skin turnover, old dead skin cells are expelled and the skin is led toward transparency. Effects are expected for those concerned about dullness.
Pore Tightening
Skin texture is refined and pores becoming less noticeable is expected. Effects are expected for those concerned about open pores.
Enhancement of Skin Barrier Function
Through strengthened skin barrier function, protection of skin from external stimuli and prevention of dryness and skin roughness are expected. This is also suitable for those with sensitive skin.
Comprehensive Skin Quality Improvement
Through continuous use, overall skin quality improves and the skin is led toward health and youthfulness. Effects are expected as a foundation for anti-aging care.
Recommended for Those Who:

Culture supernatant-containing products are suitable for individuals with the following concerns:
Those wishing to sustain clinic treatment effects. This is suitable for those wishing to maintain effects for extended periods after receiving injection or delivery treatments.
Those too busy to visit the clinic. This is suitable for those for whom regular clinic visits are difficult and those wishing to enhance home care.
Those resistant to injection or delivery treatments. This is suitable for those wishing to first try regenerative medicine through external products.
Those wishing to enhance daily skincare. This is suitable for those seeking high-quality anti-aging care products.
Those beginning to notice signs of skin aging. This is suitable for those wishing to initiate anti-aging care early.
Those with sensitive skin for whom ordinary cosmetics are unsuitable. This is suitable for those seeking low-irritation, skin-friendly products.
Our Clinic’s Commitment

At AVAN TOKYO, we provide culture supernatant-containing products with the following commitments:
Use of High-Quality Culture Supernatant
The stem cell culture supernatant formulated in products is manufactured under the same rigorous quality control as that used for clinic treatments. We are particular about growth factor and exosome content and handle only products from which effects are expected.
Skin-Friendly Formulation
The formulation minimizes components that irritate the skin, such as preservatives and fragrances. These are products that even those with sensitive skin can use with confidence.
Commitment to Penetration
The formulation is designed to ensure that active ingredients of culture supernatant penetrate the skin properly. We enhance component penetration using nanotechnology and other methods.
Usage Method Advice
To maximize product effectiveness, we advise on proper usage methods. We provide detailed explanations regarding usage amount, usage timing, combinations with other cosmetics, and other matters.
Product Lineup

Our clinic handles the following culture supernatant-containing products:
Culture Supernatant-Containing Serum
This is a serum formulated with high-concentration culture supernatant. Use after toner and before cream. It is characterized by a texture that absorbs smoothly into the skin without stickiness. It can be used for morning and evening skincare.
We offer several lineups according to concentration and volume. For first-time users, we recommend standard concentration products. For those seeking higher effects, we also offer high-concentration products.
Culture Supernatant-Containing Cream
This is a moisturizing cream formulated with culture supernatant. Use after serum to seal active ingredients into the skin. With a moist texture, it is suitable for those concerned about dryness.
Morning and evening versions are available, each formulated for respective usage scenarios. The morning version has a smooth texture easy to use before makeup; the evening version has a rich texture that provides thorough moisturization.
Culture Supernatant-Containing Eye Cream
This is an eye area-specific cream formulated with culture supernatant. Gentle on the delicate eye area skin, improvement of fine lines, sagging, dark circles, and other concerns is expected. A small amount spreads well with a non-sticky texture.
Culture Supernatant-Containing Mask
This is a sheet mask formulated with high-concentration culture supernatant. It can be used for special care once or twice weekly. Use for 10 to 15 minutes imparts firmness and luster to the skin.
Usage Method
We explain basic usage methods for culture supernatant-containing products.
Morning Skincare
After face washing, condition skin with toner. Gently blend culture supernatant-containing serum across entire face. Thinly spread culture supernatant-containing cream (morning version) across entire face. Apply sunscreen or makeup as needed.
Evening Skincare
Thoroughly remove makeup and dirt with cleansing and face washing. Condition skin with toner. Gently blend culture supernatant-containing serum across entire face. Thoroughly blend culture supernatant-containing cream (evening version) across entire face. Use eye cream for the eye area.
Special Care
Use culture supernatant-containing mask once or twice weekly. After face washing, after conditioning skin with toner, adhere mask closely to face. After 10 to 15 minutes, remove mask and blend remaining serum into skin. Afterward, use cream as usual.
Storage Method and Expiration Date
Please store culture supernatant-containing products according to the following method:
Storage Method
Avoid direct sunlight and store in a cool location. After opening, refrigerator storage is recommended. To maintain cleanliness, always close the lid securely after use.
Expiration Date
If unopened, products can be used until the date indicated on the product. After opening, please use within 2 to 3 months. Because culture supernatant contains delicate components, we recommend using as quickly as possible after opening.
Combination with Other Treatments
Culture supernatant-containing products can enhance effectiveness when used in combination with clinic treatments.
Combination with Dermal Administration
Receiving injection or delivery treatment to the skin at the clinic and caring with culture supernatant-containing products at home—through this combination, treatment effects can be maximally drawn out and sustained.
Combination with Infusion Therapy
Promoting rejuvenation from within the body through infusion and caring from outside the skin with external products—through this approach from both inside and outside, more effective rejuvenation is expected.
Combination with Other Aesthetic Treatments
By using culture supernatant-containing products after botulinum toxin, hyaluronic acid, laser treatment, and other procedures, treatment effects can be enhanced and sustained.
Regarding Fees
Fees for culture supernatant-containing products are as follows:
| Product | Fee |
|---|---|
| Culture Supernatant-Containing Serum (1 month supply) | ¥33,000–¥55,000 |
| Culture Supernatant-Containing Cream (1 month supply) | ¥44,000–¥66,000 |
| Culture Supernatant-Containing Eye Cream (1 month supply) | ¥22,000–¥33,000 |
| Culture Supernatant-Containing Mask (5 sheets) | ¥16,500–¥22,000 |
*All prices are inclusive of tax. *Fees vary depending on product type and concentration. Details will be explained during consultation.
Initial consultation and counseling fees are free. Payment is accepted via cash, credit cards, debit cards, and medical loans.
Frequently Asked Questions
We respond to questions commonly received from patients regarding culture supernatant-containing products.
What is the difference from ordinary cosmetics?
While ordinary cosmetics aim at superficial moisturization and skin conditioning, culture supernatant-containing products aim to enhance the skin’s regenerative capacity itself through active ingredients such as growth factors and exosomes.
Can those with sensitive skin use these products?
Yes, they can be used. Because the formulation minimizes components that irritate the skin, even those with sensitive skin can use them with confidence. However, when using for the first time, we recommend performing a patch test.
When can I expect to perceive effects?
Individual variation exists; however, many individuals perceive improved skin firmness and luster after approximately 1 to 2 months of continuous use. By using continuously, you can perceive effects more fully.
Can these be used in combination with other cosmetics?
Yes, they can be used in combination. After toner, use culture supernatant-containing serum, followed by cream, sunscreen, and other cosmetics you ordinarily use.
How long should these be used?
Considering skin turnover, we recommend continuing use for at least 2 to 3 months. By using long-term, you can perceive effects more fully.
Regenerative Medicine Home Care Products Available in Ginza
AVAN TOKYO provides high-quality culture supernatant-containing products in Ginza. More effective rejuvenation is expected when used in combination with clinic treatments.
Incorporating regenerative medicine into daily skincare—this is an investment in your skin. Finding it enjoyable to look in the mirror in the morning, improved makeup adherence, finding it delightful to be photographed. Please nurture beautiful skin with culture supernatant-containing products.
We conduct consultations free of charge, so please feel free to consult with us first. We will propose products tailored to each individual patient’s skin condition and provide maximum support toward realizing beautiful skin.