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Stem Cell Conditioned Media (Including Exosomes) × Morpheus82026.02.14

Cytokine-Focused Drug Delivery for Next-Generation Skin & Hair Regeneration

In regenerative medicine, increasing attention has been directed toward stem cell conditioned media (SCCM)—particularly the biological activity of the cytokines it contains.

While the precise mechanisms of exosomes alone are still under investigation, the effects of cytokines such as growth factors and anti-inflammatory mediators are supported by a growing body of basic and clinical research.

At AVAN TOKYO, we focus on localized cytokine concentration, delivering SCCM directly into target tissue using Morpheus8-based drug delivery.

Why Focus on Cytokines?

Stem cell conditioned media contains biologically active factors such as:

  • EGF (Epidermal Growth Factor) – promotes epidermal turnover and cellular regeneration
  • IGF-1 (Insulin-like Growth Factor-1) – stimulates collagen production and hair follicle activity
  • VEGF (Vascular Endothelial Growth Factor) – induces angiogenesis and improves local blood flow
  • TGF-β (Transforming Growth Factor-beta) – regulates inflammation and enhances wound healing

These molecules naturally participate in tissue repair and regeneration.

With aging and chronic inflammation, their activity declines. By delivering them locally at adequate concentrations, we aim to promote:

  • Dermal remodeling
  • Fibroblast activation
  • Improved microcirculation
  • Normalization of inflammatory environments

Why Morpheus8 Drug Delivery?

Systemic infusion dilutes biologically active factors throughout the bloodstream.

Morpheus8 combines microneedling with radiofrequency (RF) energy to:

  1. Create controlled micro-channels in the dermis
  2. Stimulate collagen remodeling through RF
  3. Allow direct penetration of SCCM into target layers

This approach enables high local concentration delivery without systemic dilution.

At approximately 1 mm depth, treatment targets the upper to mid-dermis—optimizing the synergistic effect of RF-induced remodeling and cytokine signaling.

Applications for Skin

Direct dermal delivery may support:

  • Improved firmness and elasticity
  • Reduction in pore size
  • Acne scar remodeling
  • Fine line improvement
  • Overall skin quality enhancement

Rather than adding volume, this approach aims to improve tissue quality at a structural level.

Applications for Scalp & Hair

Hair follicles are highly responsive to growth factors and vascular supply.

Localized cytokine delivery may help:

  • Support the hair growth cycle
  • Activate dormant follicles
  • Improve hair thickness
  • Reduce scalp inflammation

This therapy can complement conventional medical hair treatments.

Our Clinical Philosophy

Regenerative medicine carries significant potential—but also the risk of exaggerated claims.

At AVAN TOKYO, we emphasize:

  • Evidence-based protocols
  • Strict patient selection
  • Clear explanation of realistic expectations

Stem cell conditioned media is not a “miracle cure.”

However, cytokine-focused local drug delivery represents a biologically rational and promising strategy.

Conclusion

Morpheus8 × Stem Cell Conditioned Media is a next-generation regenerative approach targeting:

  • Dermal restructuring
  • Angiogenesis
  • Anti-inflammatory modulation
  • Hair cycle support

Grounded in tissue biology—not trends—

AVAN TOKYO continues to deliver regenerative medicine aligned with global standards.