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Morpheus8 × Stem Cell Conditioned Media (Including Exosomes)2026.01.13

Next-Generation Skin & Hair Regeneration Therapy

In regenerative medicine, global attention is increasingly focused on how to utilize Stem Cell Conditioned Media (SCCM)—which contains cytokines and exosomes—to improve tissue health.

While the scientific evidence for exosomes alone is still evolving and often surrounded by exaggerated marketing, many clinical studies have already demonstrated the biological effects of cytokines found in SCCM—such as EGF, IGF-1, VEGF, and TGF-β—on anti-inflammation, wound healing, and angiogenesis.

At AVAN TOKYO, we do not administer SCCM as an IV infusion.

Instead, we deliver it directly into the skin and scalp using Morpheus8 drug delivery, allowing higher local concentration and more targeted action.

Why Drug Delivery with Morpheus8?

1. Direct delivery to the dermis and scalp

Morpheus8 creates controlled micro-injuries while delivering RF energy, leading to:

  • Dermal collagen remodeling
  • Fibroblast stimulation
  • Micro-channel formation

These channels allow SCCM to penetrate far more effectively than IV infusion, delivering active molecules exactly where they are needed.

2. Optimized depth for dermal remodeling (1 mm setting)

We adjust depth based on treatment goals, but the 1 mm setting is ideal for upper-to-mid dermal remodeling.

Delivering SCCM here enhances:

  • EGF: Accelerated epidermal turnover
  • IGF-1: Hair follicle activation
  • VEGF: Angiogenesis → improved follicle nutrition
  • TGF-β: Anti-inflammatory, healing promotion

This synergy maximizes the biologic impact of SCCM.

3. A different mechanism from IV exosome therapy

Exosome IV therapy currently lacks strong evidence.

Its mechanism, distribution, and efficacy remain unclear, and we do not support clinics promoting it as a “miracle cure.”

However, direct local administration into skin and scalp does have growing clinical evidence, with multiple studies showing measurable benefit.

Drug delivery:

  • Avoids systemic dilution
  • Maintains high concentration in target tissue
  • Combines micro-injury with regenerative signaling

This is fundamentally different from IV infusion.

Expected Benefits

【Skin】

  • Increased dermal collagen
  • Smaller pores
  • Improved texture, firmness, radiance
  • Reduced dullness
  • Remodeling of acne scars and fine lines

【Hair & Scalp】

  • Hair follicle activation (IGF-1, FGF, VEGF)
  • Improved growth cycle
  • Thickening of thin hairs
  • Reduced scalp inflammation
  • Effective adjunct to AGA medications

What AVAN TOKYO Prioritizes

1. Accurate medical information (no exaggeration)

We do not promote exosomes as “miracle cures.”

2. Realistic expectations & transparent risk explanation

3. Evidence-based treatment protocols

Depth, concentration, RF settings, and treatment intervals are designed using the latest clinical data.

4. Commitment to true regenerative medicine principles

Morpheus8 × SCCM is not a trend—it’s the next standard

While water-injection (mesotherapy) remains a valuable method,

Morpheus8 drug delivery achieves deeper, more consistent penetration, making it one of the most promising next-generation treatments for skin quality improvement, anti-aging, and hair regeneration.