Column

Exosomes Explained: Types, Cytokine Profiles, and Clinical Applications2026.04.09

— Umbilical Cord, Dental Pulp, and Adipose-Derived Exosomes —

Exosome therapy is one of the most rapidly evolving fields in regenerative medicine.

At AVAN TOKYO, we emphasize not just using exosomes—but using the right type for the right purpose.

The origin of exosomes determines their cytokine composition, biological activity, and clinical effects.

■ What Are Exosomes?

Exosomes are nano-sized extracellular vesicles secreted by stem cells.

They contain:

  • Growth factors
  • Cytokines
  • microRNA

These components enable cell-to-cell communication, promoting:

  • Tissue repair
  • Anti-inflammatory effects
  • Regeneration

■ Three Main Types of Exosomes

① Umbilical Cord-Derived Exosomes

Characteristics: High regenerative potential and strong anti-inflammatory effects

  • Cytokine content: Very high
  • Anti-inflammatory effect: Strong
  • Tissue repair: Excellent

Indications:

  • Skin rejuvenation
  • Anti-aging
  • Post-operative recovery

② Dental Pulp-Derived Exosomes

Characteristics: Strong effects on nerves and vascular regeneration

  • Cytokine profile: Balanced
  • Neurotrophic factors: High
  • Angiogenesis: Strong

Indications:

  • Hair restoration (AGA/FAGA)
  • Scalp regeneration
  • Chronic inflammation

③ Adipose-Derived Exosomes

Characteristics: Balanced repair and anti-inflammatory effects

  • Cytokine level: Moderate to high
  • Anti-inflammatory: Stable and effective
  • Tissue remodeling: Strong

Indications:

  • Skin repair (acne scars, texture)
  • Post-liposuction recovery
  • Overall tissue regeneration

■ Why Intravenous (IV) Exosome Therapy?

Exosomes can be administered locally or systemically.

IV infusion offers whole-body benefits.

● Anti-Inflammatory Effects

  • Reduces systemic inflammation
  • Supports immune balance
  • Enhances recovery after surgery

● Cellular Environment Optimization

Exosomes circulate through the bloodstream, improving the cellular microenvironment.

● Effects on the Scalp and Hair Growth

Exosomes contribute to:

  • Activation of hair follicle stem cells
  • Angiogenesis (improved blood supply)
  • Reduction of scalp inflammation

👉 This creates an optimal environment for hair growth.

■ AVAN TOKYO’s Approach

— It’s Not “Which One,” but “How to Use Them” —

We design treatments based on:

  • Indication (skin, hair, recovery)
  • Delivery method (IV vs local)
  • Combination with devices (e.g., Morpheus8)

■ Maximizing Results with Morpheus8

Exosomes are only effective if delivered to the right depth.

With Morpheus8:

  • Direct delivery into dermis and subcutaneous layers
  • Collagen stimulation
  • Deep scalp environment remodeling

👉 Results are significantly enhanced compared to exosomes alone.

■ Final Message

Exosomes are not a universal solution—but when used correctly, they are powerful.

The key lies in:

What to use, where to deliver, and how to combine treatments.

At AVAN TOKYO, we provide precision regenerative therapy tailored to each patient.