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The Medical Significance of Delivering Stem Cell Conditioned Media (Including Exosomes) via Morpheus82026.02.15

— Designing Regenerative Medicine —

In regenerative medicine, Stem Cell Conditioned Media (containing cytokines and exosomes) has gained significant attention.

However, what truly matters is not only what we use, but how we deliver it.

At AVAN TOKYO, we do not rely on simple topical application or intravenous infusion. Instead, we utilize Morpheus8(RF microneedling) for drug delivery, based on clear medical rationale.

1. Direct High-Concentration Delivery to Target Tissue

With IV infusion or oral administration, bioactive factors circulate systemically and become diluted before reaching the target area.

Morpheus8:

  • Creates microchannels with fine needles reaching the dermis or scalp
  • Allows immediate introduction of conditioned media
  • Enables direct, high-concentration local delivery

Since skin and hair follicles are localized structures, local administration is theoretically more rational than systemic delivery.

2. Synergy with RF-Induced Wound Healing Signals

Morpheus8 is not merely a delivery device.

RF energy induces:

  • Collagen contraction
  • Fibroblast stimulation
  • Controlled micro-injury

During wound healing, cellular sensitivity to growth factors increases.

Delivering conditioned media containing:

  • EGF
  • IGF-1
  • VEGF
  • TGF-β

at this optimal timing may enhance physiological repair processes.

3. Anatomically Precise Targeting

Depth can be adjusted to reach:

  • ~1 mm → superficial to mid dermis (skin quality improvement)
  • Deeper levels → perifollicular region (hair treatment)

Topical application cannot penetrate the stratum corneum effectively.
IV infusion cannot selectively target hair follicles.

Morpheus8 allows structurally guided precision therapy.

4. Avoiding Systemic Dilution and Degradation

Growth factors and cytokines are proteins that:

  • Are easily degraded in blood
  • Undergo hepatic metabolism
  • Disperse systemically

Localized drug delivery avoids dilution and maximizes local therapeutic effect.

5. A Scientifically Responsible Position

The full mechanism of exosomes is not yet completely elucidated.

However, cytokines within conditioned media demonstrate:

  • Anti-inflammatory effects
  • Promotion of wound healing
  • Induction of angiogenesis

AVAN TOKYO does not promote this as a “miracle therapy.”

We emphasize:

Delivering the right substance,
to the right layer,
at the right concentration.

Skin and hair regeneration depends not only on what is administered, but how it is delivered.